Phenotypes Associated with This Genotype

Genotype
MGI:6852580

• Allelic Composition: Meig1^tm1.1Zzha/Meig1^tm1.1Zzha; Tg(Hspa2-cre)1Eddy/0
• Genetic Background: involves: C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:194944 )

♂N • testis weight to body weight and seminal vesicle weight to body weight ratios are normal

abnormal sperm axoneme morphology ( J:194944 )

♂ • sperm axonemes and accessory structures appear disorganized

♂ • "9 +2" axonemes are not present in the remaining flagella

absent sperm flagellum ( J:194944 )

♂ • very few flagella are formed

oligozoospermia ( J:194944 )

♂ • epididymidal sperm number is dramatically lower than that in control mice

♂ • epididymides only contain debris and degenerating spermatozoa

abnormal sperm head morphology ( J:194944 )

♂ • most of the remaining spermatozoa exhibit round or detached heads

globozoospermia ( J:194944 )

♂

abnormal sperm nucleus morphology ( J:194944 )

♂ • spermatids with enlarged redundant nuclear envelopes are observed

abnormal spermatid morphology ( J:194944 )

♂ • spermatid tails are not formed properly, and the redundant nuclear envelope appears to be enlarged

abnormal manchette assembly ( J:194944 )

♂ • manchette structures are either disrupted or absent in condensing spermatids

immotile sperm ( J:194944 )

♂ • remaining epididymidal spermatozoa show no motility

arrest of spermiogenesis ( J:194944 )

♂ • most spermatids fail to develop to the elongating stage

abnormal epididymis morphology ( J:194944 )

♂ • epididymides only contain debris and degenerating spermatozoa

male infertility ( J:194944 )

♂ • all adult males are sterile

cellular

abnormal sperm axoneme morphology ( J:194944 )

♂ • sperm axonemes and accessory structures appear disorganized

♂ • "9 +2" axonemes are not present in the remaining flagella

absent sperm flagellum ( J:194944 )

♂ • very few flagella are formed

oligozoospermia ( J:194944 )

♂ • epididymidal sperm number is dramatically lower than that in control mice

♂ • epididymides only contain debris and degenerating spermatozoa

abnormal sperm head morphology ( J:194944 )

♂ • most of the remaining spermatozoa exhibit round or detached heads

globozoospermia ( J:194944 )

♂

abnormal sperm nucleus morphology ( J:194944 )

♂ • spermatids with enlarged redundant nuclear envelopes are observed

abnormal spermatid morphology ( J:194944 )

♂ • spermatid tails are not formed properly, and the redundant nuclear envelope appears to be enlarged

abnormal manchette assembly ( J:194944 )

♂ • manchette structures are either disrupted or absent in condensing spermatids

immotile sperm ( J:194944 )

♂ • remaining epididymidal spermatozoa show no motility