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Phenotypes Associated with This Genotype
Genotype
MGI:6870515
Allelic
Composition		 Atg7tm1Tchi/Atg7tm1Tchi
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg7tm1Tchi mutation (3 available); any Atg7 mutation (51 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal autophagosome formation ( J:258511 )
• after 12 h of nutrient deprivation, tamoxifen-treated mouse embryonic fibroblasts (MEFs) fail to show canonical autophagosome formation (punctate LC3 signal), unlike wild-type MEFs

homeostasis/metabolism
abnormal autophagosome formation ( J:258511 )
• after 12 h of nutrient deprivation, tamoxifen-treated mouse embryonic fibroblasts (MEFs) fail to show canonical autophagosome formation (punctate LC3 signal), unlike wild-type MEFs

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory