About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6885893
Allelic
Composition
Golga2tm1.1Baos/Golga2tm1.2Baos
Tg(Stra8-icre)1Reb/0
Genetic
Background
involves: 129 * C57BL/6 * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Golga2tm1.1Baos mutation (0 available); any Golga2 mutation (53 available)
Golga2tm1.2Baos mutation (0 available); any Golga2 mutation (53 available)
Tg(Stra8-icre)1Reb mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• Mitotracker-positive mitochondria are abnormally found in the sperm head surrounding the deformed nucleus instead of the flagellar midpiece, suggesting improper mitochondrial sheath assembly
• Mitotracker staining revealed complete absence of the mitochondrial sheath in the midpiece of sperm tails
• Mitotracker-positive mitochondria are abnormally found in the sperm head surrounding the nucleus
• at 2 months of age, sperm heads in the cauda epididymides are round
• acrosome is absent, as shown by the absence of Afaf signal in most germ cells and of acrosome-specific protein ZP3R (aka SP56) in sperm

reproductive system
• Mitotracker-positive mitochondria are abnormally found in the sperm head surrounding the deformed nucleus instead of the flagellar midpiece, suggesting improper mitochondrial sheath assembly
• Mitotracker staining revealed complete absence of the mitochondrial sheath in the midpiece of sperm tails
• Mitotracker-positive mitochondria are abnormally found in the sperm head surrounding the nucleus
• at 2 months of age, sperm heads in the cauda epididymides are round
• acrosome is absent, as shown by the absence of Afaf signal in most germ cells and of acrosome-specific protein ZP3R (aka SP56) in sperm
• defects in spermiogenesis are observed at 2 months of age
• however, seminiferous tubule morphology is grossly normal


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/17/2024
MGI 6.24
The Jackson Laboratory