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Phenotypes Associated with This Genotype
Genotype
MGI:6887946
Allelic
Composition		 C2cd3em2Brgm/C2cd3em2Brgm
E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic
Background		 involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C2cd3em2Brgm mutation (0 available); any C2cd3 mutation (101 available)
E2f1Tg(Wnt1-cre)2Sor mutation (2 available); any E2f1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal tongue morphology ( J:308674 )
• dysmorphic tongue

cellular
abnormal cilium physiology ( J:308674 )
• increased Gli3FL/Gli3R ratio indicating the cilia are functionally impaired

skeleton
delayed bone ossification ( J:308674 )
• delayed ossification of the palatine bone at E17.5

digestive/alimentary system
abnormal tongue morphology ( J:308674 )
• dysmorphic tongue

growth/size/body
cleft palate ( J:308674 )
abnormal tongue morphology ( J:308674 )
• dysmorphic tongue

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory