Phenotypes Associated with This Genotype

Genotype
MGI:6887948

• Allelic Composition: C2cd3^{tm1c(EUCOMM)Wtsi}/C2cd3^{tm1c(EUCOMM)Wtsi}; E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal facial morphology ( J:308674 )

• midline widening detected at e11.5 which is exacerbated at E15.5

cleft palate ( J:308674 )

tongue hypoplasia ( J:308674 )

cellular

abnormal cilium physiology ( J:308674 )

• increased Gli3FL/Gli3R ratio indicating the cilia are functionally impaired

skeleton

delayed bone ossification ( J:308674 )

• delayed ossification of the palatine and sphenoid bones at E17.5

digestive/alimentary system

cleft palate ( J:308674 )

tongue hypoplasia ( J:308674 )

growth/size/body

abnormal facial morphology ( J:308674 )

• midline widening detected at e11.5 which is exacerbated at E15.5

cleft palate ( J:308674 )

tongue hypoplasia ( J:308674 )