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Phenotypes Associated with This Genotype
Genotype
MGI:7257827
Allelic
Composition		 Pfn3em1Hsc/Pfn3+
Genetic
Background		 involves: C57BL/6 * DBA
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Mouse lines carrying:
Pfn3em1Hsc mutation (0 available); any Pfn3 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:320651 )
N
• heterozygous males are fertile, produce a normal average litter size, and show no significant changes in sperm motility parameters and acrosome biogenesis relative to wild-type males
oligozoospermia ( J:320651 )
• cauda epididymal sperm count is significantly lower than that in wild-type males
• however, the percentage of viable sperm is in the normal range
abnormal sperm nucleus morphology ( J:320651 )
• 50% of DAPI-stained sperm cells show abnormal nuclear morphology similar to that observed in Pfn3em1Hsc homozygous males

cellular
oligozoospermia ( J:320651 )
• cauda epididymal sperm count is significantly lower than that in wild-type males
• however, the percentage of viable sperm is in the normal range
abnormal sperm nucleus morphology ( J:320651 )
• 50% of DAPI-stained sperm cells show abnormal nuclear morphology similar to that observed in Pfn3em1Hsc homozygous males

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory