Phenotypes Associated with This Genotype

Genotype
MGI:7257829

• Allelic Composition: Pfn3^em2Hsc/Pfn3⁺
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:320651 )

♂N • heterozygous males are fertile, produce a normal average litter size, and show no significant changes in sperm motility parameters and acrosome biogenesis relative to wild-type males

oligozoospermia ( J:320651 )

♂ • cauda epididymal sperm count is significantly lower than that in wild-type males

♂ • however, the percentage of viable sperm is in the normal range

abnormal sperm head morphology ( J:320651 )

♂

abnormal sperm nucleus morphology ( J:320651 )

♂ • 50% of DAPI-stained sperm cells show abnormal nuclear morphology similar to that observed in Pfn3^em2Hsc homozygous males

cellular

oligozoospermia ( J:320651 )

♂ • cauda epididymal sperm count is significantly lower than that in wild-type males

♂ • however, the percentage of viable sperm is in the normal range

abnormal sperm head morphology ( J:320651 )

♂

abnormal sperm nucleus morphology ( J:320651 )

♂ • 50% of DAPI-stained sperm cells show abnormal nuclear morphology similar to that observed in Pfn3^em2Hsc homozygous males