Analysis Tools
mortality/aging
|
• shorter life span, with mice starting to die around 20 weeks of age and 50% survival at around 40 weeks of age
|
behavior/neurological
|
• mice develop an abnormal hindlimb reflex, characterized by hindlimb retraction when lifted by the tail from 8 weeks of age
|
|
• mice show unstable walking and tremor-like movements that become increasing severe with age
|
|
• mice show progressive motor impairment on the accelerating rotarod which is prominent by 12 weeks of age
|
|
• mice show progressive motor weakening on the hanging wire test at about 12 weeks of age
|
|
• mice show abnormal gait, with irregularly spaced shorter strides and uneven left-right step pattern at 1 year of age
|
|
• mice show irregularly spaced shorter strides at 1 year of age
|
hematopoietic system
microgliosis
(
J:287782
)
|
• microgliosis in the frontal cortex
|
immune system
microgliosis
(
J:287782
)
|
• microgliosis in the frontal cortex
|
nervous system
microgliosis
(
J:287782
)
|
• microgliosis in the frontal cortex
|
astrocytosis
(
J:287782
)
|
• reactive astrocytosis in the frontal cortex
|
|
• the number of nuclear bodies known as Gemini of coiled bodies in cortical neurons of motor cortex is reduced
|
