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Phenotypes Associated with This Genotype
Genotype
MGI:7336222
Allelic
Composition		 Prmt9em1Cya/Prmt9em1Cya
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Prmt9em1Cya mutation (0 available); any Prmt9 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased circulating interferon-beta level ( J:328263 )
• in the serum of mice infected with VSV
increased interferon-beta secretion ( J:328263 )
• from macrophages infected with SeV or stimulated with 5'pppRNA
decreased susceptibility to viral infection ( J:328263 )
• mice infected with VSV exhibit reduced IFBN-beta serum levels, viral titers in the lung, liver, and spleen, inflammation, edema, and pulmonary fibrosis compared with wild-type mice
• however, response to HSV-1 infection is normal

homeostasis/metabolism
increased circulating interferon-beta level ( J:328263 )
• in the serum of mice infected with VSV

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory