Phenotypes Associated with This Genotype

Genotype
MGI:7345566

• Allelic Composition: Osr2^tm5(cre)Jian/Osr2⁺; Tg(CAG-Nog)1Ych/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal secondary palate development ( J:310908 )

• shelves are separated from each other and smaller at E14.5 and E16.5

• extraversive hypophosphatasia

• significant decrease in both muscle and mesenchymal cell proliferation at the tensor veli palatini and levator veli palatini levels at E13.5 and E14.5

• increase in apoptosis at the the tensor veli palatini, levator veli palatini, and palatopharyngeus levels

• expression analysis indicates impaired development of the aponeurosis and tendons of the soft palate

palatal shelf hypoplasia ( J:310908 )

• hypoplastic muscle tissue

abnormal palatine aponeurosis morphology ( J:310908 )

• expression analysis indicates impaired development of the aponeurosis of the soft palate

small levator veli palatini muscle ( J:310908 )

• only a few sparsely distributed myofibers are present at E14.5

• at E16.5, myofibers become even looser and shorter compared to E14.5

abnormal palatopharyngeus muscle morphology ( J:310908 )

• at E16.5 the palatopharyngeus is smaller with fewer myofibers

small tensor veli palatini muscle ( J:310908 )

• mildly smaller at E14.5 and dramatically smaller at E16.5

muscle

small levator veli palatini muscle ( J:310908 )

• only a few sparsely distributed myofibers are present at E14.5

• at E16.5, myofibers become even looser and shorter compared to E14.5

abnormal palatopharyngeus muscle morphology ( J:310908 )

• at E16.5 the palatopharyngeus is smaller with fewer myofibers

small tensor veli palatini muscle ( J:310908 )

• mildly smaller at E14.5 and dramatically smaller at E16.5

abnormal superior pharyngeal constrictor muscle morphology ( J:310908 )

• at E16.5 the superior pharyngeal constrictor is smaller with fewer myofibers

digestive/alimentary system

abnormal secondary palate development ( J:310908 )

• shelves are separated from each other and smaller at E14.5 and E16.5

• extraversive hypophosphatasia

• significant decrease in both muscle and mesenchymal cell proliferation at the tensor veli palatini and levator veli palatini levels at E13.5 and E14.5

• increase in apoptosis at the the tensor veli palatini, levator veli palatini, and palatopharyngeus levels

• expression analysis indicates impaired development of the aponeurosis and tendons of the soft palate

palatal shelf hypoplasia ( J:310908 )

• hypoplastic muscle tissue

abnormal palatine aponeurosis morphology ( J:310908 )

• expression analysis indicates impaired development of the aponeurosis of the soft palate

small levator veli palatini muscle ( J:310908 )

• only a few sparsely distributed myofibers are present at E14.5

• at E16.5, myofibers become even looser and shorter compared to E14.5

abnormal palatopharyngeus muscle morphology ( J:310908 )

• at E16.5 the palatopharyngeus is smaller with fewer myofibers

small tensor veli palatini muscle ( J:310908 )

• mildly smaller at E14.5 and dramatically smaller at E16.5

growth/size/body

abnormal secondary palate development ( J:310908 )

• shelves are separated from each other and smaller at E14.5 and E16.5

• extraversive hypophosphatasia

• significant decrease in both muscle and mesenchymal cell proliferation at the tensor veli palatini and levator veli palatini levels at E13.5 and E14.5

• increase in apoptosis at the the tensor veli palatini, levator veli palatini, and palatopharyngeus levels

• expression analysis indicates impaired development of the aponeurosis and tendons of the soft palate

palatal shelf hypoplasia ( J:310908 )

• hypoplastic muscle tissue

abnormal palatine aponeurosis morphology ( J:310908 )

• expression analysis indicates impaired development of the aponeurosis of the soft palate

small levator veli palatini muscle ( J:310908 )

• only a few sparsely distributed myofibers are present at E14.5

• at E16.5, myofibers become even looser and shorter compared to E14.5

abnormal palatopharyngeus muscle morphology ( J:310908 )

• at E16.5 the palatopharyngeus is smaller with fewer myofibers

small tensor veli palatini muscle ( J:310908 )

• mildly smaller at E14.5 and dramatically smaller at E16.5

respiratory system

abnormal superior pharyngeal constrictor muscle morphology ( J:310908 )

• at E16.5 the superior pharyngeal constrictor is smaller with fewer myofibers