Analysis Tools
mortality/aging
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• die between E12.5 and P0
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• no live pups at birth
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craniofacial
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• at E18.5
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• absence of the processus styloidus cartilage at E18.5
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• hypoplastic and clefted at E18.5
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• hypoplastic and clefted at E18.5
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• at E18.5
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• at E18.5
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• hypoplastic at E18.5
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• hypoplasia of the zygomatic process of the squamosal bone
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• at E18.5
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• widening of the space between the nasal pits at E10.5
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• facial subepidermal blebbing at E14.5 and facial hemorrhaging at E10.5 in some embryos
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• at E18.5
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• not ossified in 2 and hypoplastic in the third of three mice that survived to E18.5
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• hypoplastic at E18.5
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• hypoplastic at E18.5
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• at E18.5
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• hypoplastic at E18.5
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• hypoplastic at E18.5
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• at E18.5
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• at E18.5 facial bones and cartilages tend to be hypoplastic in the 3 surviving mice
• elements in the middle of the face are more severely affected
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• at E18.5
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• at E18.5 hypoplastic with clefting in one
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• at E18.5 hypoplasia of the premaxilla and frontal process of the premaxilla
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• at E18.5
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• at E18.5
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• absence of the palatal process of the palatine, palatine, ala temporalis, lamina obturans and ectotympanic bones
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• in 2 of 3 surviving mice at E18.5
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• at E18.5
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• at E12.5
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• hypoplastic facial processes at E10.5
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• at E12.5 and at E14.5
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facial cleft
(
J:308882
)
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• at E12.5 the medial nasal process fail to fuse at the midline
• clefting is more pronounced at E14.5 with a striking cleft at the midline of the upper jaw and subtler cleft in the mandible
• at E18.5 the anterior part of the face is cleft in 3 surviving embryos
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hearing/vestibular/ear
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• at E18.5
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nervous system
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• at E11.5 in 19% of embryos
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• at E10.5
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• at E12.5
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• misshapen at E12.5
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• at E10.5 and E14.5
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• at E12.5
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exencephaly
(
J:308882
)
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• at E14.5
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cardiovascular system
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• facial hemorrhaging in a third of embryos at E10.5
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digestive/alimentary system
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• absence of the palatal process of the palatine, palatine, ala temporalis, lamina obturans and ectotympanic bones
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• in 2 of 3 surviving mice at E18.5
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• at E18.5
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• at E12.5
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• at E12.5 and at E14.5
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embryo
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• at E11.5 in 19% of embryos
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respiratory system
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• at E18.5
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• widening of the space between the nasal pits at E10.5
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• at E18.5
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• at E18.5
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• misshapen and occasionally fused at E18.5
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skeleton
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• absence of the processus styloidus cartilage at E18.5
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• at E18.5
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• hypoplastic and clefted at E18.5
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• hypoplastic and clefted at E18.5
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• at E18.5
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• at E18.5
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• hypoplastic at E18.5
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• hypoplasia of the zygomatic process of the squamosal bone
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• at E18.5
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• not ossified in 2 and hypoplastic in the third of three mice that survived to E18.5
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• hypoplastic at E18.5
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• hypoplastic at E18.5
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• at E18.5
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• hypoplastic at E18.5
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• hypoplastic at E18.5
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• at E18.5
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• at E18.5 facial bones and cartilages tend to be hypoplastic in the 3 surviving mice
• elements in the middle of the face are more severely affected
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• at E18.5
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• at E18.5 hypoplastic with clefting in one
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• at E18.5 hypoplasia of the premaxilla and frontal process of the premaxilla
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• at E18.5
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• at E18.5
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• absence of the palatal process of the palatine, palatine, ala temporalis, lamina obturans and ectotympanic bones
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• in 2 of 3 surviving mice at E18.5
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• at E18.5
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• hypoplasia of the middle ear cartilages at E18.5
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• at E18.5
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• at E18.5
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• at E18.5
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• misshapen and occasionally fused at E18.5
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growth/size/body
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• facial subepidermal blebbing at E14.5 and facial hemorrhaging at E10.5 in some embryos
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• at E18.5
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• not ossified in 2 and hypoplastic in the third of three mice that survived to E18.5
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• hypoplastic at E18.5
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• hypoplastic at E18.5
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• at E18.5
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• hypoplastic at E18.5
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• hypoplastic at E18.5
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• at E18.5
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• at E18.5 facial bones and cartilages tend to be hypoplastic in the 3 surviving mice
• elements in the middle of the face are more severely affected
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• at E18.5
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• at E18.5 hypoplastic with clefting in one
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• at E18.5 hypoplasia of the premaxilla and frontal process of the premaxilla
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• at E18.5
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• at E18.5
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• absence of the palatal process of the palatine, palatine, ala temporalis, lamina obturans and ectotympanic bones
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• in 2 of 3 surviving mice at E18.5
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• at E18.5
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• at E12.5
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• hypoplastic facial processes at E10.5
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• at E12.5 and at E14.5
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facial cleft
(
J:308882
)
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• at E12.5 the medial nasal process fail to fuse at the midline
• clefting is more pronounced at E14.5 with a striking cleft at the midline of the upper jaw and subtler cleft in the mandible
• at E18.5 the anterior part of the face is cleft in 3 surviving embryos
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microcephaly
(
J:308882
)
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• in 3 mice surviving to E18.5
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