Phenotypes Associated with This Genotype

Genotype
MGI:7346394

• Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺; Srsf3^tm1Pjln/Srsf3^tm1Pjln
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

decreased cranial neural crest cell apoptosis ( J:308882 )

• decreased apoptosis of cranial neural crest cells that is slight at E8.0, over 30-fold at E9.5 and 4-fold at E10.5

decreased cranial neural crest cell proliferation ( J:308882 )

• considerable at E8.0, modest at E9.5, and 4-fold at E10.5

abnormal cranial neural crest cell morphology ( J:308882 )

• reduced intensity of reporter expressing cells in the frontonasal prominence and pharyngeal arch 1 at E9.5 and throughout the facial processes at E10.5

• absence of obvious NCC streams entering the pharyngeal arches at E10.5

cellular

decreased cranial neural crest cell apoptosis ( J:308882 )

• decreased apoptosis of cranial neural crest cells that is slight at E8.0, over 30-fold at E9.5 and 4-fold at E10.5

decreased cranial neural crest cell proliferation ( J:308882 )

• considerable at E8.0, modest at E9.5, and 4-fold at E10.5

nervous system

abnormal cranial neural crest cell morphology ( J:308882 )

• reduced intensity of reporter expressing cells in the frontonasal prominence and pharyngeal arch 1 at E9.5 and throughout the facial processes at E10.5

• absence of obvious NCC streams entering the pharyngeal arches at E10.5