Phenotypes Associated with This Genotype

Genotype
MGI:7424963

• Allelic Composition: 4933425B07Rik^{Tn(pb-Act-RFP)1.1Zhu}/4933425B07Rik^{Tn(pb-Act-RFP)1.1Zhu}
• Genetic Background: involves: FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal renal/urinary system morphology ( J:313930 )

• newborn mice exhibit a significantly higher incidence (66.7%) of congenital anomalies of the kidney and urinary tract (CAKUT) than heterozygous (10.4%) or wild-type mice (9.3%)

abnormal kidney morphology ( J:313930 )

• 82.4% of newborns exhibit renal hypo/dysplasia

decreased renal glomerulus number ( J:313930 )

• newborns with hydronephrosis show a reduced number of glomeruli

• however, newborns with renal hypo/dysplasia and duplex kidneys show normal glomerulus structure and morphology

hydronephrosis ( J:313930 )

• 5.9% of newborns exhibit hydronephrosis, along with decreased numbers of glomeruli and renal tubules

renal hypoplasia ( J:313930 )

• 82.4% of newborns exhibit renal hypo/dysplasia

decreased renal tubule number ( J:313930 )

• newborns with hydronephrosis show a reduced number of renal tubules

• however, newborns with renal hypo/dysplasia and duplex kidneys show normal renal tubule structure and morphology

duplex kidney ( J:313930 )

• 8.8% of newborns exhibit duplex renal/collecting system

vesicoureteral reflux ( J:313930 )

• 2.9% of newborns exhibit vesicoureteral reflux