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Phenotypes Associated with This Genotype
Genotype
MGI:7424971
Allelic
Composition		 4933425B07RikTn(pb-Act-RFP)1.1Zhu/4933425B07RikTn(pb-Act-RFP)1.1Zhu
Tg(Hoxb7-Venus*)17Cos/0
Genetic
Background		 involves: C57BL/6J * CBA/J * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
4933425B07RikTn(pb-Act-RFP)1.1Zhu mutation (0 available); any 4933425B07Rik mutation (0 available)
Tg(Hoxb7-Venus*)17Cos mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal metanephric ureteric bud development ( J:313930 )
• expression levels of Bmp4 (a key gene regulating ureteral bud branching) are significantly reduced in the embryonic kidney during the early UB branching stages
impaired branching involved in ureteric bud morphogenesis ( J:313930 )
• in vitro, E11.5 embryonic kidneys show a significantly lower number of ureteric bud (UB) branches than control kidneys after 24, 48, and 72 h in culture

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory