Phenotypes Associated with This Genotype

Genotype
MGI:7438244

• Allelic Composition: E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺; Snrpb^em1Lajm/Snrpb⁺; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * CD1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:326544 )

• pups born alive die between P1 and P2

• however, most pups do survive to birth unlike in mutant mice wild-type for Trp53

craniofacial

abnormal mandible morphology ( J:326544 )

• asymmetric and abnormal development of the lower jaw

micrognathia ( J:326544 )

• at E18.5

cleft palate ( J:326544 )

short snout ( J:326544 )

• at E18.5

skeleton

abnormal mandible morphology ( J:326544 )

• asymmetric and abnormal development of the lower jaw

micrognathia ( J:326544 )

• at E18.5

abnormal bone ossification ( J:326544 )

• reduced ossification of the frontal bone

growth/size/body

cleft palate ( J:326544 )

short snout ( J:326544 )

• at E18.5

microcephaly ( J:326544 )

• at E18.5

digestive/alimentary system

cleft palate ( J:326544 )