Phenotypes Associated with This Genotype

Genotype
MGI:7442514

• Allelic Composition: Srgap1^{tm1a(KOMP)Wtsi}/Srgap1^{tm1a(KOMP)Wtsi}; Tg(NPHS2-cre)295Lbh/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * SJL
• Cell Lines: EPD0153_3_C10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:333727 )

N • unchallenged mice exhibit no overt renal phenotype up to 24 weeks of age, as assessed by measurement of albuminuria and histology

increased mesangial cell number ( J:333727 )

• increased mesangial cell proliferation in response to doxorubicin-induced podocyte injury

albuminuria ( J:333727 )

• increased urinary albumin-creatinine ratio in response to doxorubicin-induced podocyte injury

glomerulosclerosis ( J:333727 )

• increased segmental glomerulosclerosis in response to doxorubicin-induced podocyte injury

homeostasis/metabolism

albuminuria ( J:333727 )

• increased urinary albumin-creatinine ratio in response to doxorubicin-induced podocyte injury

increased susceptibility to injury ( J:333727 )

• following injection of adriamycin (doxorubicin) at 6 weeks of age to induce podocyte injury, 14-week-old mice exhibit histologic lesions and a significantly higher urinary albumin-creatinine ratio and glomerulosclerosis score than similarly treated control mice

cellular

increased mesangial cell number ( J:333727 )

• increased mesangial cell proliferation in response to doxorubicin-induced podocyte injury