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Phenotypes Associated with This Genotype
Genotype
MGI:7447283
Allelic
Composition
Mef2atm1.1Limm/Mef2atm1.1Limm
Mef2ctm1Jjs/Mef2ctm1Jjs
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: 129S/SvEv * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mef2atm1.1Limm mutation (0 available); any Mef2a mutation (36 available)
Mef2ctm1Jjs mutation (1 available); any Mef2c mutation (34 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• reduced sprouting angiogenesis in retina at age P5 (4 days after endothelial-cell-specific KO induction): reduced vascular density and coverage in vascular plexus and reduced number of tip cells at angiogenic front
• reduced sprouting angiogenesis in retina at age P5 (4 days after endothelial-cell-specific KO induction): reduced vascular density and coverage in vascular plexus and reduced number of tip cells at angiogenic front

vision/eye
• reduced sprouting angiogenesis in retina at age P5 (4 days after endothelial-cell-specific KO induction): reduced vascular density and coverage in vascular plexus and reduced number of tip cells at angiogenic front


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory