Phenotypes Associated with This Genotype

Genotype
MGI:7451043

• Allelic Composition: Commd10^{Tg(Vav1-icre)A2Kio}/0; Map3k7^tm1.1Arte/Map3k7^tm1.1Arte
• Genetic Background: involves: C57BL/10 * C57BL/6J * C57BL/6NTac * CBA/Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged spleen ( J:332172 )

increased neutrophil cell number ( J:332172 )

• more splenic neutrophils

increased lymphocyte cell number ( J:332172 )

• more B cells

• normal number of T cells

increased B cell number ( J:332172 )

• more splenic B cells

decreased macrophage cell number ( J:332172 )

• in bone marrow

increased splenocyte number ( J:332172 )

enlarged axillary lymph nodes ( J:332172 )

enlarged inguinal lymph nodes ( J:332172 )

decreased interleukin-10 secretion ( J:332172 )

• by BMDMs after 8h stimulation with Pam3CSK4, R848 or LPS

decreased interleukin-12b secretion ( J:332172 )

• by BMDMs after 8h stimulation with Pam3CSK4, R848 or LPS

• by peritoneal neutrophils after 7h and 16h stimulation with Pam3CSK4, R848 or LPS

decreased interleukin-6 secretion ( J:332172 )

• by peritoneal neutrophils after 7h and 16h stimulation with Pam3CSK4, R848 or LPS

• by BMDMs after 8h stimulation with Pam3CSK4 or R848

• by BMDMs after 4h stimulation with LPS

• normal by BMDMs after 8h stimulation with LPS

decreased tumor necrosis factor secretion ( J:332172 )

• by BMDMs after 8h stimulation with Pam3CSK4 or R848

• by peritoneal neutrophils after 7h and 16h stimulation with Pam3CSK4, R848 or LPS

• by BMDMs after 4h stimulation with LPS

• normal by BMDMs after 8h stimulation with LPS

hematopoietic system

enlarged spleen ( J:332172 )

increased neutrophil cell number ( J:332172 )

• more splenic neutrophils

increased lymphocyte cell number ( J:332172 )

• more B cells

• normal number of T cells

increased B cell number ( J:332172 )

• more splenic B cells

decreased macrophage cell number ( J:332172 )

• in bone marrow

increased splenocyte number ( J:332172 )

growth/size/body

enlarged spleen ( J:332172 )