Phenotypes for Eif2ak2 Hdac8 MGI:7491953 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Eif2ak2^tm1Cwe/Eif2ak2^tm1Cwe Hdac8^tm1.2Eno/Y
Genetic Background	involves: 129/Sv * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2ak2^tm1Cwe mutation (2 available); any Eif2ak2 mutation (41 available)
Hdac8^tm1.2Eno mutation (0 available); any Hdac8 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:297059 )

• viability is increased up to 57% for mutant mice homozygous for the mutation in Eif2ak2 compared to mutant mice wild-type for Eif2ak2 (~30% viability)

limbs/digits/tail

abnormal limb morphology ( J:297059 )

• increase in forelimb length compared to mutant mice wild-type for Eif2ak2

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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