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Phenotypes Associated with This Genotype
Genotype
MGI:7531572
Allelic
Composition		 1700010I14Rikem1Osb/1700010I14Rikem1Osb
Tsnaxip1em1Osb/Tsnaxip1em1Osb
Genetic
Background		 involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
1700010I14Rikem1Osb mutation (2 available); any 1700010I14Rik mutation (37 available)
Tsnaxip1em1Osb mutation (2 available); any Tsnaxip1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased hyperactivated sperm motility ( J:340908 )
• spermatozoa exhibit low maximum bending angles of the midpiece in primary anti-hook
• curvature in capacitating medium, indicating impaired hyperactivation
decreased sperm progressive motility ( J:340908 )
• spermatozoa exhibit impaired motility with circular travel paths
• flagellar beating pattern of spermatozoa shows an asymmetric waveform
reduced male fertility ( J:340908 )
• mice exhibit impaired fertility but are not infertile
• however, spermatozoa exhibit normal morphology

cellular
decreased hyperactivated sperm motility ( J:340908 )
• spermatozoa exhibit low maximum bending angles of the midpiece in primary anti-hook
• curvature in capacitating medium, indicating impaired hyperactivation
decreased sperm progressive motility ( J:340908 )
• spermatozoa exhibit impaired motility with circular travel paths
• flagellar beating pattern of spermatozoa shows an asymmetric waveform

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory