Phenotypes Associated with This Genotype

Genotype
MGI:7543479

• Allelic Composition: Sox7^tm1.1Dsco/Sox7⁺; Wnt4^{tm2(EGFP/cre/ERT2)Amc}/Wnt4⁺
• Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality during fetal growth through weaning, incomplete penetrance ( J:338879 )

• although present in normal ratios at E15.5/E16.5, double heterozygotes are recovered at lower than Mendelian ratios at weaning; however, increase in lethality between E15.5/E16.5 and weaning does not reach statistical significance

cardiovascular system

atrioventricular cushion hypoplasia ( J:338879 )

• at E10.5, atrioventricular (AV) endocardial cushions are hypocellular with a significant reduction in mesenchymal cell density relative to wild-type and single heterozygous controls

ventricular septal defect ( J:338879 )

• at E15.5, three of 8 (38%) of double heterozygotes develop VSDs, not observed in wild-type or single heterozygous controls

perimembraneous ventricular septal defect ( J:338879 )

• at E15.5, two of 8 double heterozygotes develop perimembranous VSDs

muscular ventricular septal defect ( J:338879 )

• at E15.5, one of 8 double heterozygotes shows a muscular VSD