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Phenotypes Associated with This Genotype
Genotype
MGI:7543562
Allelic
Composition		 Tg(Cd4-cre)1Cwi/0
Trmt61aem1Hbgl/Trmt61aem1Hbgl
Genetic
Background		 involves: C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-cre)1Cwi mutation (10 available)
Trmt61aem1Hbgl mutation (0 available); any Trmt61a mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD4-positive T cell differentiation ( J:336736 )
• TCR-dependent T cell differentiation exhibit reduced potential to become Th1, Th17, and in vitro-induced Treg cells compared with wild-type cells
increased CD4-positive, alpha-beta T cell number ( J:336736 )
• increased in the lymph nodes
increased CD8-positive, alpha-beta T cell number ( J:336736 )
• increased in the lymph nodes
abnormal T cell activation ( J:336736 )
• in peripheral lymphatic organs
decreased T cell proliferation ( J:336736 )
• after treatment with anti-CD3and anti-CD28 antibodies
• however, apoptosis rates remain wild-type

digestive/alimentary system

hematopoietic system
abnormal CD4-positive T cell differentiation ( J:336736 )
• TCR-dependent T cell differentiation exhibit reduced potential to become Th1, Th17, and in vitro-induced Treg cells compared with wild-type cells
increased CD4-positive, alpha-beta T cell number ( J:336736 )
• increased in the lymph nodes
increased CD8-positive, alpha-beta T cell number ( J:336736 )
• increased in the lymph nodes
abnormal T cell activation ( J:336736 )
• in peripheral lymphatic organs
decreased T cell proliferation ( J:336736 )
• after treatment with anti-CD3and anti-CD28 antibodies
• however, apoptosis rates remain wild-type

cellular
decreased T cell proliferation ( J:336736 )
• after treatment with anti-CD3and anti-CD28 antibodies
• however, apoptosis rates remain wild-type

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory