Phenotypes Associated with This Genotype

Genotype
MGI:7544909

• Allelic Composition: Mib1^em1Jlp/Mib1^tm2Kong; Tg(Tnnt2-cre)5Blh/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal trabecula carnea morphology ( J:338889 )

• noncompacted trabeculae in ventricular myocardium in adults

thin left ventricle myocardium compact layer ( J:338889 )

• left ventricular compact layer 45% thinner in E16.5 embryos

• reduced compact-to-trabecular myocardium ratio in E16.5 embryos

abnormal cardiac outflow tract development ( J:338889 )

• various conotruncal defects in E16.5 embryos

abnormal aortic valve morphology ( J:338889 )

• dysplasia in adults

bicuspid aortic valve ( J:338889 )

• in E16.5 embryos

dilated heart ventricle ( J:338889 )

• in adults

cardiac fibrosis ( J:338889 )

• myocardial fibrosis in septum and around coronary vessels in adults

decreased cardiac muscle contractility ( J:338889 )

• reduced fractional shortening and ejection fraction in adults

aortic valve regurgitation ( J:338889 )

• in adults

mortality/aging

lethality during fetal growth through weaning, incomplete penetrance ( J:338889 )

• only 5% of embryos develop to adulthood

muscle

abnormal trabecula carnea morphology ( J:338889 )

• noncompacted trabeculae in ventricular myocardium in adults

thin left ventricle myocardium compact layer ( J:338889 )

• left ventricular compact layer 45% thinner in E16.5 embryos

• reduced compact-to-trabecular myocardium ratio in E16.5 embryos

decreased cardiac muscle contractility ( J:338889 )

• reduced fractional shortening and ejection fraction in adults