Phenotypes Associated with This Genotype

Genotype
MGI:7578823

• Allelic Composition: Tulp4^{tm1a(KOMP)Wtsi}/Tulp4⁺
• Genetic Background: involves: C57BL/6N * C57BL/6NRj
• Cell Lines: EPD0112_4_G12

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:344151 )

N • despite a broad range of anatomic abnormalities detected at E14.5, mice exhibit normal prenatal and postnatal survival

cardiovascular system

cardiovascular system phenotype ( J:344151 )

N • adult mice show no signs of thrombosis or vascular disease; blood vessels of different organs (including lung, liver, and spleen) and sections of the heart and aortic valves show no evidence of blood clots, anatomical abnormalities, or vascular defects at the cellular level

abnormal artery morphology ( J:344151 )

• at E14.5, four of 7 embryos show abnormal morphology of the head arteries or the vertebral artery

abnormal vertebral artery morphology ( J:344151 )

abnormal liver vasculature morphology ( J:344151 )

• at E14.5, five of 7 embryos show abnormal liver vasculature

abnormal hepatic portal vein connection ( J:344151 )

• abnormal connection of branches of right liver and portal vein at E14.5

dual inferior vena cava ( J:344151 )

• at E14.5, two of 7 embryos show dual inferior vena cava

telangiectasia ( J:344151 )

• at E14.5, one of 7 embryos shows telangiectasia

growth/size/body

increased body weight ( J:344151 )

• longitudinal weighting of a large mouse cohort under controlled conditions showed a trend for increased body weight at an age of 26 weeks for males and 38 weeks for females; in males, weight differences become significant at 62 and 66 weeks of age

lung cyst ( J:344151 )

• at E14.5, one of 7 embryos shows a blood-filled cyst in the lung

liver/biliary system

abnormal liver vasculature morphology ( J:344151 )

• at E14.5, five of 7 embryos show abnormal liver vasculature

muscle

telangiectasia ( J:344151 )

• at E14.5, one of 7 embryos shows telangiectasia

abnormal infrahyoid muscle morphology ( J:344151 )

• at E14.5, two of 7 embryos show anomalies affecting the infrahyoid muscles

skeleton

abnormal sternum morphology ( J:344151 )

• at E14.5, one of 7 embryos shows sternal malformation with abnormal morphology of sternal ridges

abnormal rib development ( J:344151 )

• at E14.5, one of 7 embryos shows abnormal rib development

nervous system

thin hypoglossal nerve ( J:344151 )

• at E14.5, one of 7 embryos shows a thin hypoglossal nerve unilaterally

reproductive system

abnormal testis tissue architecture ( J:344151 )

• at E14.5, one of 7 embryos shows abnormal testis tissue architecture

respiratory system

lung cyst ( J:344151 )

• at E14.5, one of 7 embryos shows a blood-filled cyst in the lung

abnormal infrahyoid muscle morphology ( J:344151 )

• at E14.5, two of 7 embryos show anomalies affecting the infrahyoid muscles

homeostasis/metabolism

subcutaneous edema ( J:344151 )

• at E14.5, two of 7 embryos with absent connection between the subcutaneous lymph vessels and lymph sacs show subcutaneous edema

hematopoietic system

hematopoietic system phenotype ( J:344151 )

N • adult mice show no evidence of aberrant hematopoiesis

immune system

immune system phenotype ( J:344151 )

N • adult mice show no evidence of immunological abnormalities; immunophenotyping of peripheral blood and bone marrow showed no quantitative alterations in leukocytes and leukocyte subsets

absent connection between subcutaneous lymph vessels and lymph sac ( J:344151 )

• at E14.5, two of 7 embryos show a missing connection between the subcutaneous lymph vessels and left lymph sac in conjunction with subcutaneous edema

endocrine/exocrine glands

abnormal testis tissue architecture ( J:344151 )

• at E14.5, one of 7 embryos shows abnormal testis tissue architecture

integument

subcutaneous edema ( J:344151 )

• at E14.5, two of 7 embryos with absent connection between the subcutaneous lymph vessels and lymph sacs show subcutaneous edema