Phenotypes Associated with This Genotype

Genotype
MGI:7595582

• Allelic Composition: Efr3b^tm1Gpt/Efr3b^tm1Gpt; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:344437 )

N • locomotion and spatial and fear memory are similar to controls

N • olfactory habituation/dishabituation is similar to controls

abnormal response to social novelty ( J:344437 )

• fail to show a preference for a novel stranger mouse over a stranger mouse encountered in the past at 8 weeks of age but not at 12 weeks of age

• however, response to a novel object s similar to controls and preference for a stranger mouse compared to an empty chamber is similar to controls

nervous system

nervous system phenotype ( J:344437 )

N • brain size is similar to controls

abnormal nervous system electrophysiology ( J:344437 )

• in hippocampal slices from 8 week old but not 12 week old mice, resting membrane potential, input resistance, and initial frequency are significantly decreased

• rheobase (minimal currant amplitude to elicit spike discharge) is increased in dorsal CA2 pyramidal neurons

• however, resting membrane potential, input resistance, and rheobase in the dCA3 pyramidal neurons are similar to controls

impaired ability to fire action potentials ( J:344437 )

• decreased number of action potentials in response to depolarizing current injections in CA2 pyramidal neurons