Analysis Tools
growth/size/body
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• male mice fed a chow diet show a significant decrease in body weight relative to single Ldlrtm1Her homozygotes
• however, female body weight is similar to that in single Ldlrtm1Her homozygotes
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homeostasis/metabolism
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• both male and female mice fed a chow diet show a significant reduction in plasma total cholesterol concentration relative to single Ldlrtm1Her homozygotes
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• both male and female mice fed a standard chow diet show a decreased plasma cholesterol concentration within LDL fractions
• however, the amount of circulating LDL particles is similar to that in single Ldlrtm1Her homozygotes in both sexes, as measured by ApoB protein abundance at the apex of the LDL-C peak and within the triglyceride-rich lipoproteins
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• male mice fed a chow diet show a significant reduction in plasma triglyceride concentration relative to single Ldlrtm1Her homozygotes
• however, female plasma triglyceride levels are not significantly different from those in single Ldlrtm1Her homozygotes
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• both male and female mice fed a chow diet show a significant reduction in liver total cholesterol concentration relative to single Ldlrtm1Her homozygotes
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• both male and female mice fed a chow diet show a significant reduction in liver triglyceride concentration relative to single Ldlrtm1Her homozygotes
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liver/biliary system
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• both male and female mice fed a chow diet show a significant reduction in liver total cholesterol concentration relative to single Ldlrtm1Her homozygotes
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• both male and female mice fed a chow diet show a significant reduction in liver triglyceride concentration relative to single Ldlrtm1Her homozygotes
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• male mice fed a chow diet show a significant decrease in liver weight relative to single Ldlrtm1Her homozygotes
• however, liver weight to body weight ratio is unaffected in males, and no differences in liver weight or liver weight to body weight ratio are observed in female mice relative to single Ldlrtm1Her homozygotes
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