Phenotypes Associated with This Genotype

Genotype
MGI:7657888

• Allelic Composition: Ctps1^{tm1c(KOMP)Wtsi}/Ctps1^{tm1c(KOMP)Wtsi}; Commd10^{Tg(Vav1-icre)A2Kio}/0
• Genetic Background: B6.Cg-Ctps1^{tm1c(KOMP)Wtsi} Commd10^{Tg(Vav1-icre)A2Kio}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:348981 )

• mice do not survive after 6 weeks of age

prenatal lethality, incomplete penetrance ( J:348981 )

• fewer than the expected numbers of mice are obtained

endocrine/exocrine glands

small thymus ( J:348981 )

thymus hypoplasia ( J:348981 )

• cellularity of thymus is reduced

growth/size/body

decreased body size ( J:348981 )

hematopoietic system

decreased T cell proliferation ( J:348981 )

• double positive cells are reduced and single positive CD4 and CD8 cells are increased, suggesting reduced proliferation of double negative thymocytes leading to double positive stage

small thymus ( J:348981 )

thymus hypoplasia ( J:348981 )

• cellularity of thymus is reduced

anemia ( J:348981 )

• severe anemia

decreased bone marrow cell number ( J:348981 )

• bone marrow cellularity is reduced, with the percentage of Ter119+ bone marrow cells, corresponding to erythrocyte progenitors, is strongly decreased

• absolute numbers of erythroid and hematopoietic progenitors are reduced as bone marrow cellularity is reduced

• however, the percentage of LSK+ cells in bone marrow is normal

decreased B cell number ( J:348981 )

• absolute numbers of B lymphocytes are reduced in the spleen

decreased NK cell number ( J:348981 )

• absolute numbers of NK cells are reduced in the spleen

increased CD4-positive, alpha-beta T cell number ( J:348981 )

increased CD8-positive, alpha-beta T cell number ( J:348981 )

decreased T cell number ( J:348981 )

• absolute numbers of T lymphocytes are reduced in the spleen

decreased double-positive T cell number ( J:348981 )

decreased hematopoietic stem cell number ( J:348981 )

• absolute numbers of hematopoietic progenitors are reduced as bone marrow cellularity is reduced

decreased megakaryocyte-erythroid progenitor cell number ( J:348981 )

• the percentage of Ter119+ bone marrow cells, corresponding to erythrocyte progenitors, is strongly decreased

abnormal spleen morphology ( J:348981 )

• spleen cellularity is normal but absolute numbers of B and T lymphocytes and NK cells are reduced, while macrophages and granulocytes are not affected

immune system

decreased T cell proliferation ( J:348981 )

• double positive cells are reduced and single positive CD4 and CD8 cells are increased, suggesting reduced proliferation of double negative thymocytes leading to double positive stage

small thymus ( J:348981 )

thymus hypoplasia ( J:348981 )

• cellularity of thymus is reduced

decreased B cell number ( J:348981 )

• absolute numbers of B lymphocytes are reduced in the spleen

decreased NK cell number ( J:348981 )

• absolute numbers of NK cells are reduced in the spleen

increased CD4-positive, alpha-beta T cell number ( J:348981 )

increased CD8-positive, alpha-beta T cell number ( J:348981 )

decreased T cell number ( J:348981 )

• absolute numbers of T lymphocytes are reduced in the spleen

decreased double-positive T cell number ( J:348981 )

abnormal spleen morphology ( J:348981 )

• spleen cellularity is normal but absolute numbers of B and T lymphocytes and NK cells are reduced, while macrophages and granulocytes are not affected

cellular

decreased T cell proliferation ( J:348981 )

• double positive cells are reduced and single positive CD4 and CD8 cells are increased, suggesting reduced proliferation of double negative thymocytes leading to double positive stage