Analysis Tools
adipose tissue
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• on a high fat diet
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• on a high fat diet fat partitioning is altered with increased subcutaneous fat, gonadal depot and decreased liver fat
• however, body weight, lean mass and overall fat mass are similar to controls
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• on a high fat diet
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behavior/neurological
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• food intake is reduced and treatment with leptin further reduces food intake compared to wild-type controls
• food intake is reduced on normal chow and high fat diets
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homeostasis/metabolism
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• levels of fasted metabolic hormones (leptin, insulin, C-peptide, glucagon, ghrelin, GLP1, amylin) are similar to controls
• on a high fat diet, energy expenditure, locomotor activity, and respiratory exchange ratio are similar to controls on both a normal chow and high fat diet
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• glucose tolerance is preserved in mice after 4 weeks on a high fat diet unlike in diet matched wild-type controls
• on a normal chow diet glucose tolerance is similar to controls
• after 10 weeks on a high fat diet glucose intolerance is mild compared to diet matched wild-type controls
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• in mice on a high fat diet compared to diet matched wild-type controls
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• in mice on a high fat diet compared to a diet matched wild-type controls
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• decreased expression of inflammatory cytokines in mice on a high fat diet
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liver/biliary system
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• in mice on a high fat diet
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immune system
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• decreased expression of inflammatory cytokines in mice on a high fat diet
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• decrease in expression of inflammatory cytokines and markers of infiltrating macrophages in the liver and adipose tissue in mice on a high fat diet
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integument
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• on a high fat diet
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