Phenotypes for Styxl1 MGI:7703723 MGI Mouse

reproductive system phenotype ( J:351148 )

N	• testes to body weight ratio is similar to controls

oligozoospermia ( J:351148 )

• extrememly reduced numbers in the cauda epididymis

teratozoospermia ( J:351148 )

• sperm from the cauda epididymis show severe morphological defects including abnormal heads and bent or coiled tails

abnormal sperm flagellum morphology ( J:351148 )

• apparent scarcity of flagella at stage VII-VIII

• defects in formation are detected at step 9 during spermiogenesis

abnormal outer dense fiber morphology ( J:351148 )

• displaced

abnormal sperm axoneme morphology ( J:351148 )

• displaced microtubules

• abnormal '9+2' atructure

absent sperm axonemal central pair ( J:351148 )

• in the midpiece or principal piece

abnormal sperm end piece morphology ( J:351148 )

• absence of microtubules

coiled sperm flagellum ( J:351148 )

abnormal sperm head morphology ( J:351148 )

abnormal acrosome morphology ( J:351148 )

• elongating spermatids undergoing spermiogenesis show deformed acrosomes

abnormal sperm nucleus morphology ( J:351148 )

• nuclear abnormalities are seen starting at step 10 in elongating spermatids

• elongating spermatids undergoing spermiogenesis show abnormally constricted nuclei at the site of perinuclear rings and deformed acrosome and malformed nuclei

abnormal spermatid morphology ( J:351148 )

• nuclear abnormalities are seen starting at step 10 in elongating spermatids and fewer tails are present in the lumen at stage VII-VIII

• elongating spermatids undergoing spermiogenesis show abnormally constricted nuclei at the site of perinuclear rings, deformed acrosome and malformed nuclei, and asymmetric and abnormally elongated manchette microtubules

abnormal manchette morphology ( J:351148 )

• elongating spermatids undergoing spermiogenesis show asymmetric and abnormally elongated manchette microtubules

elongated manchette ( J:351148 )

• elongated abnormally along the nuclear surface

decreased sperm progressive motility ( J:351148 )

asthenozoospermia ( J:351148 )

male infertility ( J:351148 )

• males are completely infertile