Phenotypes Associated with This Genotype

Genotype
MGI:7704170

• Allelic Composition: Nkx2-5^tm2(cre)Rph/Nkx2-5⁺; Slmap^tm1.1Tuab/Slmap^tm1.1Tuab
• Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:346063 )

N • no abnormalities are detected in cardiomyocyte proliferation during cardiogenesis

N • no abnormalities detected in adult cardiac function or morphology

abnormal atrioventricular cushion morphology ( J:346063 )

• delay in septation indicated by absence of cushion of the atrioventricular cushions at E12.5

• however, by E16.5 septation is complete

decreased fetal cardiomyocyte size ( J:346063 )

• at E12.5 in the left ventricle

decreased heart atrium wall thickness ( J:346063 )

small heart ( J:346063 )

• significantly smaller at E9.5, E12.5, and E16.5

• however, by P0 and P7 heart size is similar to wild-type controls

thin ventricular wall ( J:346063 )

decreased heart left ventricle wall thickness ( J:346063 )

• significantly thinner at E9.5, E12.5, and E16.5

• however, by P7 wall thickness is similar to wild-type controls