Phenotypes Associated with This Genotype

Genotype
MGI:7720058

• Allelic Composition: Nup54^em1(IMPC)Bay/Nup54^em1(IMPC)Bay
• Genetic Background: C57BL/6NJ-Nup54^em1(IMPC)Bay/Mmnc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Nup54^em1(IMPC)Bay/Nup54^em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos show severe developmental delay as small egg cylinders, poorly organized extraembryonic tissues, and no gastrulation.

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• homozygous embryos are present in expected Mendelian ratios at E7.5; no homozygous embryos are recovered at E9.5

embryo

failure to gastrulate ( J:279207 )

• embryos fail to initiate gastrulation; no Brachyury (T)-positive cells are present at E7.5

embryonic growth retardation ( J:279207 )

• embryos show a severe developmental delay at E7.5

decreased egg cylinder size ( J:279207 )

• a small egg cylinder is observed at E7.5

failure of primitive streak formation ( J:279207 )

• no Brachyury (T)-positive cells are present at E7.5

disorganized extraembryonic tissue ( J:279207 )

• extraembryonic tissues are poorly organized at E7.5

growth/size/body

embryonic growth retardation ( J:279207 )

• embryos show a severe developmental delay at E7.5