Phenotypes Associated with This Genotype

Genotype
MGI:7720268

• Allelic Composition: Nars1^em1(IMPC)Bay/Nars1^em1(IMPC)Bay
• Genetic Background: C57BL/6N-Nars1^em1(IMPC)Bay/Mmmh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Nars1^em1(IMPC)Bay/Nars1^em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts do not hatch from the zona pellucida or form outgrowths in culture.

mortality/aging

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• blastocyst-like embryos are present in expected Mendelian ratios at E3.5; no homozygous embryos are recovered at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

embryo

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro, blastocysts fail to hatch from the zona pellucida after 3 days in culture

reproductive system

failure of embryo implantation ( J:279207 )

• in vitro outgrowth assays show that blastocysts do not hatch or form outgrowths after 3 days in culture