Phenotypes Associated with This Genotype

Genotype
MGI:7782473

• Allelic Composition: Lepr^tm1Rck/Lepr^tm1Rck; Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/Ndor1⁺
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

obese ( J:344866 )

• mice gain approximately 17-19 grams over 4 weeks after tamoxifen treatment

homeostasis/metabolism

increased circulating leptin level ( J:344866 )

• tamoxifen-treated mice develop hyperleptinemia

• hyperleptinemia in tamoxifen-treated mice is resistant to auranofin treatment

decreased physiological sensitivity to xenobiotic ( J:344866 )

• tamoxifen-treated mice lack metabolic responses to the drug auranofin, with no effect on hyperleptinemia, food intake, respiratory exchange ratio, activity, insulin and glucose tolerance, fasting insulin levels, or fatty liver and auranofin treatment does not increase fasting serum free fatty acids as in wild-type mice

• tamoxifen-treated mice lack the anti-inflammatory responses to auranofin in epididymal white adipose tissue (eWAT) that are seen in wild-type mice and auranofin treatment does not increase eWAT oxygen consumption rates