Tbk1tm1Aki
Targeted Allele Detail
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|
| Symbol: |
Tbk1tm1Aki |
| Name: |
TANK-binding kinase 1; targeted mutation 1, Shizuo Akira |
| MGI ID: |
MGI:3046789 |
| Synonyms: |
Tbk1- |
| Gene: |
Tbk1 Location: Chr10:121382360-121422692 bp, - strand Genetic Position: Chr10, 69.84 cM
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| Alliance: |
Tbk1tm1Aki page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:91363
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| Parent Cell Line: |
E14.1 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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| |
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Mutation details: Exon 9 was replaced with a neomycin resistance gene. Northern blot indicated the absence of protein in mutant MEFs.
(J:91363)
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| Key: |
| hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
|
Genotype/
Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
|---|
Loading... | | | involves: 129P2/OlaHsd * C57BL/6 | | | | involves: 129P2/OlaHsd * C57BL/6 * CBA | |
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| Phenotypes: |
| Affected Systems |
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hematopoietic system
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√
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decreased IgG level
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√
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decreased IgG1 level
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√
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decreased IgG2a level
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√
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abnormal cytotoxic T cell physiology
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√
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decreased cytotoxic T cell cytolysis
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√
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immune system
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√
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decreased IgG level
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√
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decreased IgG1 level
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√
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decreased IgG2a level
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√
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abnormal cytotoxic T cell physiology
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√
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decreased cytotoxic T cell cytolysis
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√
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decreased interferon-gamma secretion
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√
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mortality/aging
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√
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N
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mortality/aging
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N
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lethality throughout fetal growth and development, complete penetrance
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Tbk1 Mutation: |
57 strains or lines available
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|
| Original: |
J:91363 Hemmi H, et al., The Roles of Two IkappaB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection. J Exp Med. 2004 Jun 21;199(12):1641-50 |
| All: |
33 reference(s) |
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Analysis Tools
