Tbk1<tm1Aki> Targeted Allele Detail MGI Mouse (MGI:3046789)

Tbk1^tm1Aki
Targeted Allele Detail

Summary

Symbol:	Tbk1^tm1Aki
Name:	TANK-binding kinase 1; targeted mutation 1, Shizuo Akira
MGI ID:	MGI:3046789
Synonyms:	Tbk1^-
Gene:	Tbk1 Location: Chr10:121382360-121422692 bp, - strand Genetic Position: Chr10, 69.84 cM
Alliance:	Tbk1^tm1Aki page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:91363
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exon 9 was replaced with a neomycin resistance gene. Northern blot indicated the absence of protein in mutant MEFs. (J:91363)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Tbk1 Mutation:	56 strains or lines available

References

Original:	J:91363 Hemmi H, et al., The Roles of Two IkappaB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection. J Exp Med. 2004 Jun 21;199(12):1641-50
All:	32 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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