Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Lyz2tm1(cre)Ifo
Name:	lysozyme 2; targeted mutation 1, Irmgard Forster
MGI ID:	MGI:1934631
Synonyms:	LC, LCre, Lys-cre, LysCre, lysM/cre, LysMcre, LysM Cre, LysM-Cre, LysMCre, LysMCre, Lystm1(cre)Ifo, Lyz2-Cre, Lyz2Cre, Lyz-cre, LyzCre, (LyzM)-Cre
Gene:	Lyz2  Location: Chr10:117113446-117118177 bp, - strand  Genetic Position: Chr10, 65.34 cM
Alliance:	Lyz2tm1(cre)Ifo page

Germline Transmission:	Earliest citation of germline transmission: J:67924
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Lyz2tm1(cre)Ifo expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Lyz2 (MGI:96897)   Mutation details: An NLS-cre gene was inserted into the endogenous ATG start site of the gene. An frt-flanked neomycin cassette was removed in ES cells via Flp-mediated recombination prior to production of chimeric mice. (J:67924)

Activity:	Tissue activity of this recombinase allele
Driver:	Lyz2 (mouse) Summary of all recombinase alleles driven by Lyz2. Comparative matrix view of recombinase activities Alliance mouse Lyz2 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	13 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

List all tumor models in MMHCdb carrying Lyz2tm1(cre)Ifo

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 14 strains available      Cell Lines: 0 lines available
Carrying any Lyz2 Mutation:	40 strains or lines available

Original:	J:67924 Clausen BE, et al., Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res. 1999 Aug;8(4):265-77
All:	2569 reference(s)