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Jag1tm1Jlew
Targeted Allele Detail
Summary
Symbol: Jag1tm1Jlew
Name: jagged 1; targeted mutation 1, Julian Lewis
MGI ID: MGI:3623344
Synonyms: Jag1flox
Gene: Jag1  Location: Chr2:136923371-136958440 bp, - strand  
Alliance: Jag1tm1Jlew page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:107414
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: LoxP sites were inserted to flank exons encoding the DSL (Delta-Serrate-Lag2) domain required for binding to Notch. Expression of cre recombinase is expected to knock out gene function by removing exons 4 and 5 (the DSL encoding exons) and causing a frame shift that generates a stop codon after the start of exon 6. (J:107414)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 42 assay results
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jag1 Mutation:  78 strains or lines available
References
Original:  J:107414 Brooker R, et al., Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear. Development. 2006 Apr;133(7):1277-86
All:  31 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory