About   Help   FAQ
Pfn2tm1Wit
Targeted Allele Detail
Summary
Symbol: Pfn2tm1Wit
Name: profilin 2; targeted mutation 1, Walter Witke
MGI ID: MGI:3715145
Synonyms: pfn2-
Gene: Pfn2  Location: Chr3:57749316-57755178 bp, - strand  Genetic Position: Chr3, 28.15 cM
Alliance: Pfn2tm1Wit page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:122603
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: The beta-geo cassette was inserted into exon 3, thereby disrupting the reading frame. Western blot confirmed absence of protein in brain lysates from mutant mice. (J:122603)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pfn2 Mutation:  7 strains or lines available
References
Original:  J:122603 Pilo Boyl P, et al., Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior. EMBO J. 2007 Jun 20;26(12):2991-3002
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory