Npc1<tm1.1Apl> Targeted Allele Detail MGI Mouse (MGI:4431252)

Npc1^tm1.1Apl
Targeted Allele Detail

Summary

Symbol:	Npc1^tm1.1Apl
Name:	NPC intracellular cholesterol transporter 1; targeted mutation 1.1, Andrew P Lieberman
MGI ID:	MGI:4431252
Synonyms:	Npc1^flox
Gene:	Npc1 Location: Chr18:12322749-12369457 bp, - strand Genetic Position: Chr18, 6.15 cM
Alliance:	Npc1^tm1.1Apl page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:157113
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1^a

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: Exon 9 was floxed. An frt-flanked neo cassette inserted downstream of exon 9 was removed by flp mediated recombination. (J:157113)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Npc1 Mutation:	74 strains or lines available

References

Original:	J:157113 Elrick MJ, et al., Conditional Niemann-Pick C mice demonstrate cell autonomous Purkinje cell neurodegeneration. Hum Mol Genet. 2010 Mar 1;19(5):837-47
All:	7 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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