Pgd<tm1a(EUCOMM)Wtsi> Targeted Allele Detail MGI Mouse (MGI:4431737)

About Help FAQ

Pgd^{tm1a(EUCOMM)Wtsi}
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Pgd^{tm1a(EUCOMM)Wtsi}
Name:	phosphogluconate dehydrogenase; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID:	MGI:4431737
Gene:	Pgd Location: Chr4:149234448-149251162 bp, - strand Genetic Position: Chr4, 78.96 cM
Alliance:	Pgd^{tm1a(EUCOMM)Wtsi} page
IMPC:	Pgd gene page

Mutation
origin

Mutant Cell Lines:	EPD0117_4_B02, EPD0117_4_B03, EPD0117_4_C01, EPD0117_4_C02, EPD0117_4_C03, EPD0117_4_D01, EPD0117_4_D03, EPD0117_4_E01, EPD0117_4_E02, EPD0117_4_F01, EPD0117_4_F02, EPD0117_4_F03, EPD0117_4_G01, EPD0117_4_G02, EPD0117_4_G03, EPD0117_4_H03
Germline Transmission:	Earliest citation of germline transmission: J:165965
Parent Cell Line:	JM8.N4 (ES Cell)
Strain of Origin:	C57BL/6N
Project Collection:	EUCOMM

Mutation
description

Allele Type:		Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:		Insertion Vector: L1L2_gt0
		Mutation details: The L1L2_gt0 cassette was inserted at position 149245059 of Chromosome 4 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 149245886. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 1 line available
Carrying any Pgd Mutation:	21 strains or lines available

References

Original:	J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:	5 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24