Srsf4<tm1a(EUCOMM)Wtsi> Targeted Allele Detail MGI Mouse (MGI:4431961)

Srsf4^{tm1a(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

Symbol:	Srsf4^{tm1a(EUCOMM)Wtsi}
Name:	serine and arginine-rich splicing factor 4; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID:	MGI:4431961
Gene:	Srsf4 Location: Chr4:131600928-131629017 bp, + strand Genetic Position: Chr4, 64.53 cM
Alliance:	Srsf4^{tm1a(EUCOMM)Wtsi} page
IMPC:	Srsf4 gene page

Mutation
origin

Mutant Cell Lines:	EPD0039_1_A07, EPD0039_1_A08, EPD0039_1_B08, EPD0039_1_C07, EPD0039_1_C08, EPD0039_1_C09, EPD0039_1_D07, EPD0039_1_D08, EPD0039_1_D09, EPD0039_1_E07, EPD0039_1_E08, EPD0039_1_F07, EPD0039_1_F08, EPD0039_1_G07, EPD0039_1_G08, EPD0039_1_G09, EPD0039_1_H07, EPD0039_1_H08, EPD0039_1_H09
Germline Transmission:	Earliest citation of germline transmission: J:165965
Parent Cell Line:	JM8.N4 (ES Cell)
Strain of Origin:	C57BL/6N
Project Collection:	EUCOMM

Mutation
description

Allele Type:		Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:		Insertion Vector: L1L2_gt2
		Mutation details: The L1L2_gt2 cassette was inserted at position 131618285 of Chromosome 4 upstream of the critical exon 2 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of exon 2 at position 131618884. Exon 2 is thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 1 line available
Carrying any Srsf4 Mutation:	46 strains or lines available

References

Original:	J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:	7 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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