Trib3tm1a(EUCOMM)Hmgu
Targeted Allele Detail
|
|
| Symbol: |
Trib3tm1a(EUCOMM)Hmgu |
| Name: |
tribbles pseudokinase 3; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH |
| MGI ID: |
MGI:4435061 |
| Gene: |
Trib3 Location: Chr2:152179342-152185952 bp, - strand Genetic Position: Chr2, 74.83 cM
|
| Alliance: |
Trib3tm1a(EUCOMM)Hmgu page
|
| IMPC: |
Trib3 gene page |
|
| Mutant Cell Lines: |
HEPD0510_8_A06, HEPD0510_8_B05, HEPD0510_8_B06, HEPD0510_8_B07, HEPD0510_8_B08, HEPD0510_8_C07, HEPD0510_8_D06, HEPD0510_8_D08, HEPD0510_8_E06, HEPD0510_8_E08, HEPD0510_8_F05, HEPD0510_8_F06, HEPD0510_8_F07, HEPD0510_8_F08, HEPD0510_8_G05, HEPD0510_8_G06, HEPD0510_8_H05, HEPD0510_8_H06, HEPD0510_8_H07, HEPD0510_8_H08 |
| Germline Transmission: |
Earliest citation of germline transmission:
J:165965
|
| Parent Cell Line: |
JM8.N4 (ES Cell)
|
| Strain of Origin: |
C57BL/6N
|
| Project Collection: |
EUCOMM
|
|
| Allele Type: |
|
Targeted (Conditional ready, Null/knockout, Reporter) |
| Mutation: |
|
Insertion
Vector: L1L2_Bact_P
|
| |
|
Mutation details: The L1L2_Bact_P cassette was inserted at position 152181348 of Chromosome 2 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 152182350. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:157065)
|
|
|
|
|
| Original: |
J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015; |
| All: |
4 reference(s) |
|
Analysis Tools
