Tmod3<tm1a(EUCOMM)Hmgu> Targeted Allele Detail MGI Mouse (MGI:4435232)

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Tmod3^{tm1a(EUCOMM)Hmgu}
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Summary

Symbol:	Tmod3^{tm1a(EUCOMM)Hmgu}
Name:	tropomodulin 3; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
MGI ID:	MGI:4435232
Gene:	Tmod3 Location: Chr9:75405066-75466939 bp, - strand Genetic Position: Chr9, 42.3 cM
Alliance:	Tmod3^{tm1a(EUCOMM)Hmgu} page
IMPC:	Tmod3 gene page

Mutation
origin

Mutant Cell Lines:	HEPD0547_3_A05, HEPD0547_3_A07, HEPD0547_3_B05, HEPD0547_3_B06, HEPD0547_3_B07, HEPD0547_3_B08, HEPD0547_3_C05, HEPD0547_3_C06, HEPD0547_3_C07, HEPD0547_3_C08, HEPD0547_3_D07, HEPD0547_3_E06, HEPD0547_3_E07, HEPD0547_3_F05, HEPD0547_3_F06, HEPD0547_3_F07, HEPD0547_3_F08, HEPD0547_3_G05, HEPD0547_3_G06, HEPD0547_3_G08, HEPD0547_3_H05, HEPD0547_3_H08
Germline Transmission:	Earliest citation of germline transmission: J:204812
Parent Cell Line:	JM8.N4 (ES Cell)
Strain of Origin:	C57BL/6N
Project Collection:	EUCOMM

Mutation
description

Allele Type:		Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:		Insertion Vector: L1L2_Bact_P
		Mutation details: The L1L2_Bact_P cassette was inserted at position 75436400 of Chromosome 9 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 75437295. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 1 line available
Carrying any Tmod3 Mutation:	29 strains or lines available

References

Original:	J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015;
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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