Tcf7<tm1a(EUCOMM)Wtsi> Targeted Allele Detail MGI Mouse (MGI:4441645)

Tcf7^{tm1a(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

Symbol:	Tcf7^{tm1a(EUCOMM)Wtsi}
Name:	transcription factor 7, T cell specific; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID:	MGI:4441645
Gene:	Tcf7 Location: Chr11:52143198-52174158 bp, - strand Genetic Position: Chr11, 31.86 cM
Alliance:	Tcf7^{tm1a(EUCOMM)Wtsi} page
IMPC:	Tcf7 gene page

Mutation
origin

Mutant Cell Lines:	EPD0023_2_A11, EPD0023_2_A12, EPD0023_2_B10, EPD0023_2_B12, EPD0023_2_C11, EPD0023_2_C12, EPD0023_2_D10, EPD0023_2_D11, EPD0023_2_D12, EPD0023_2_E10, EPD0023_2_E11, EPD0023_2_F10, EPD0023_2_F11, EPD0023_2_F12, EPD0023_2_G10, EPD0023_2_G11, EPD0023_2_G12, EPD0023_2_H10, EPD0023_2_H12
Germline Transmission:	Earliest citation of germline transmission: J:165965
Parent Cell Line:	C2 (Nagy) (ES Cell)
Strain of Origin:	C57BL/6NTac
Project Collection:	EUCOMM

Mutation
description

Allele Type:		Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:		Insertion Vector: L1L2_gt0
		Mutation details: The L1L2_gt0 cassette was inserted at position 52151908 of Chromosome 11 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 52153021. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 1 line available
Carrying any Tcf7 Mutation:	26 strains or lines available

References

Original:	J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:	11 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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