Ptprc<b> Allele Detail MGI Mouse (MGI:4819850)

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Ptprc^b
Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Ptprc^b
Name:	protein tyrosine phosphatase receptor type C; b variant
MGI ID:	MGI:4819850
Synonyms:	CD45.2, Ly5^b
Gene:	Ptprc Location: Chr1:137990599-138103446 bp, - strand Genetic Position: Chr1, 60.73 cM
Alliance:	Ptprc^b page

Mutation
origin

Strain of Origin:

Not Applicable

Mutation
description

Allele Type:		Not Applicable
Mutation:		Nucleotide substitutions
		Mutation details: Ptprc^b is found in strains C57BL/6, C3H/An, DBA/2, AKR, and many others (J:13367, J:12054, J:12077, J:8603). Twelve nucleotide differences between the a and b alleles have been identified. These base substitutions correspond to five amino-acid changes within the extracellular domain of the encoded protein. These amino-acid differences are clustered in a region that also contains the greatest divergence between mouse and rat sequences (J:22485). Note that the allele designations originally described were reversed in 1987 (J:8603); all publications prior to 1987 show SJL/J, STS/A, and DA as having the b allele and the C57BL/6J group as having the a allele (J:22341). (J:8080, J:12548, J:22485)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 8 strains available Cell Lines: 0 lines available
Carrying any Ptprc Mutation:	189 strains or lines available

References

Original:	J:12077 Komuro K, et al., Ly-5: a new lymphocyte antigen system. Immunogenetics. 1975;1:452-456
All:	39 reference(s)

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