Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | Notes | References

Symbol:	Tg(Nes-cre)1Kln
Name:	transgene insertion 1, Rudiger Klein
MGI ID:	MGI:2176173
Synonyms:	n-Cre+, Nes11Cre, NesCre, nestin-Cre, nestin/Cre, Nestin:Cre, Tg(Nes-cre), Tg(Nest-cre)1Jln, TgN(NesCre)1Kln
Transgene:	Tg(Nes-cre)1Kln  Location: Chr12:90491366-90491383 bp  Genetic Position: Chr12, Syntenic
Alliance:	Tg(Nes-cre)1Kln page

Strain of Origin:

(C57BL/6 x SJL)F2

Transgene Type:    Transgenic (Recombinase) Mutations:    Insertion, Intergenic deletion   Tg(Nes-cre)1Kln expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note rat Nes (25491) Nes  (MGI:101784)   Mutation details: This transgene expresses Cre recombinase with a human growth hormone polyadenylation signal under the control of a rat nestin (Nes) promoter and the nervous system-specific enhancer present in the second intron. This promoter expresses Cre recombinase in neuronal and glial cell precursors. Cre recombinase activity is present in nervous tissue by embryonic day 11. The transgene was localized to chromosome 12 using FISH with a rat nestin promoter probe (J:180046). The insertion caused a 17 bp deletion. (J:57315, J:133340, J:164338, J:180046)

Activity:	Tissue activity of this recombinase allele
Driver:	Nes (rat) Summary of all recombinase alleles driven by Nes. Comparative matrix view of recombinase activities Alliance rat Nes gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1447 assay results 69 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

List all tumor models in MMHCdb carrying Tg(Nes-cre)1Kln

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available      Cell Lines: 0 lines available

Original:	J:57315 Tronche F, et al., Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet. 1999 Sep;23(1):99-103
All:	1395 reference(s)