Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | Notes | References

Symbol: Tg(Lck-cre)548Jxm Name: transgene insertion 548, Jamey Marth MGI ID: MGI:2176199 Synonyms: Lck-cre, pLck-cre, Tg(Lck-cre), TgN(Lck-cre)548Jxm Transgene: Tg(Lck-cre)548Jxm  Location: unknown  Genetic Position: Chr11, Syntenic Alliance: Tg(Lck-cre)548Jxm page

Lung and salivary gland inflammation in Tgfb1tm2.1Doe/Tgfb1tm2.1Doe Tg(Lck-cre)548Jxm/? (b,e) and Tgfb1tm1Doe/Tgfb1tm2.1Doe Tg(Lck-cre)548Jxm/? (c,f) mice Show the 1 phenotype image(s) involving this allele.

Strain of Origin:

(C57BL/6 x CBA)F2

Transgene Type:    Transgenic (Recombinase) Mutations:    Duplication, Insertion   Tg(Lck-cre)548Jxm expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Lck (MGI:96756)   Mutation details: This transgene expresses Cre recombinase with a human growth hormone polyadenylation signal under the control of the mouse lck promoter, active in the T cell lineage. Transgene insertion occurred on Chr11, causing a 1 bp duplication. (J:67674)

Activity:	Tissue activity of this recombinase allele
Driver:	Lck (mouse) Summary of all recombinase alleles driven by Lck. Comparative matrix view of recombinase activities Alliance mouse Lck gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Tg(Lck-cre)548Jxm

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:67674 Hennet T, et al., T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination. Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12070-4
All:	225 reference(s)