Ptprftm1a(EUCOMM)Wtsi
Targeted Allele Detail
|
|
| Symbol: |
Ptprftm1a(EUCOMM)Wtsi |
| Name: |
protein tyrosine phosphatase receptor type F; targeted mutation 1a, Wellcome Trust Sanger Institute |
| MGI ID: |
MGI:4887720 |
| Gene: |
Ptprf Location: Chr4:118065410-118148602 bp, - strand Genetic Position: Chr4, 54.47 cM, cytoband C6-D1
|
| Alliance: |
Ptprftm1a(EUCOMM)Wtsi page
|
| IMPC: |
Ptprf gene page |
|
| Mutant Cell Line: |
EPD0697_1_D03 |
| Germline Transmission: |
Earliest citation of germline transmission:
J:307756
|
| Parent Cell Line: |
JM8A3.N1 (ES Cell)
|
| Strain of Origin: |
C57BL/6N-Atm1Brd
|
| Project Collection: |
EUCOMM
|
|
| Allele Type: |
|
Targeted (Conditional ready, Null/knockout, Reporter) |
| Mutation: |
|
Insertion
Vector: L1L2_Bact_P
|
| |
|
Mutation details: The L1L2_Bact_P cassette was inserted at position 118092573 of Chromosome 4 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 118095566. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:155845, J:173534)
|
|
|
|
|
| Original: |
J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010; |
| All: |
4 reference(s) |
|
Analysis Tools
