Dll4<tm1Frad> Targeted Allele Detail MGI Mouse (MGI:3828266)

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Dll4^tm1Frad
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Dll4^tm1Frad
Name:	delta like canonical Notch ligand 4; targeted mutation 1, Freddy Radtke
MGI ID:	MGI:3828266
Synonyms:	DL4^lox
Gene:	Dll4 Location: Chr2:119156286-119166145 bp, + strand Genetic Position: Chr2, 59.97 cM, cytoband E3
Alliance:	Dll4^tm1Frad page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:143472
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: A loxP site was inserted into the 5' untranslated region and an frt-flanked neo cassette with a loxP site was inserted into intron 3. Germ line, flp mediated recombination was used to remove the neo cassette leaving exons 1 through 3 floxed. (J:143472)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	25 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Dll4 Mutation:	27 strains or lines available

References

Original:	J:143472 Koch U, et al., Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J Exp Med. 2008 Oct 27;205(11):2515-23
All:	30 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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