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Tg(Bmx-cre/ERT2)1Rha
Transgene Detail
Summary
Symbol: Tg(Bmx-cre/ERT2)1Rha
Name: transgene insertion 1, Ralf H Adams
MGI ID: MGI:5513853
Synonyms: Bmx(PAC)-CreERT2
Transgene: Tg(Bmx-cre/ERT2)1Rha  Location: unknown  
Alliance: Tg(Bmx-cre/ERT2)1Rha page
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F1
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(Bmx-cre/ERT2)1Rha expression driven by 1 gene
 
Mutation details: cDNA encoding cre recombinase fused to the mutated human estrogen receptor ligand-binding domain (ERT2) and followed by a polyadenylation signal and an Frt-flanked neo cassette was inserted into the start codon of the mouse Bmx gene located in the P1 artificial chromosome (PAC; RPCI21) using recombineering methods. Flp-mediated excision in bacteria removed the neo marker. The validated construct was injected into fertilized oocytes to generate founders (details not available). Founders were bred to reporter mice to assess recombination efficiency and specificity; mice display inducible artery-specific cre activity. (J:198633)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Bmx (mouse)
Summary of all recombinase alleles driven by Bmx.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:198633 Ehling M, et al., Notch controls retinal blood vessel maturation and quiescence. Development. 2013 Jul;140(14):3051-61
All:  23 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory