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Ptentm1.1Jaes
Targeted Allele Detail
Summary
Symbol: Ptentm1.1Jaes
Name: phosphatase and tensin homolog; targeted mutation 1.1, Jose A Esteban
MGI ID: MGI:5796481
Synonyms: PtendeltaPDZ, Ptentm(Q399stop)amc
Gene: Pten  Location: Chr19:32734977-32803560 bp, + strand  Genetic Position: Chr19, 28.14 cM
Alliance: Ptentm1.1Jaes page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:234430
Parent Cell Line:  iTL1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation details: The PDZ-binding domain was deleted by substituting glutamine codon 399 (CAA) with a stop codon (TAA) in exon 8. Cre-mediated recombination removed the loxp-flanked neomycin cassette downstream of exon 8. (J:234430)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pten Mutation:  88 strains or lines available
References
Original:  J:234430 Knafo S, et al., PTEN recruitment controls synaptic and cognitive function in Alzheimer's models. Nat Neurosci. 2016 Mar;19(3):443-53
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory